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This approach can be generally applied to repurposing drugs for other brain disorders simply by connecting any disease-associated genes or SNPs with the gene co-expression modules associated with normal human brain samples

Brain Res Bull 116:6772 Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of alzheimer disease amyloid neuropathology by calorie restriction

The immobilized template can be reused in the next IVT reaction at least six times

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SIRT3, as a deacetylase in mitochondria, modulates the transcription of mitochondrial in response to oxidative stress