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NNMT is nicotinamide N-methyltransferase, an enzyme that uses a methyl donor to convert nicotinamide into 1-methylnicotinamide

Further, the conversion of both hydroxycobalamin and cyanocobalamin to the active Adenosyl and methyl cobalamins, also involve "Flavoproteins" (Obeid etal, 2015) and hence if a person takes or is injected with, high doses of hydroxycobalamin or cyanocobalamin and has functional B2 deficiency, the inactive hydroxycobalamin and cyanocobalamin will accumulate in serum, however the symptoms of vitamin B12 deficiency will not be resolved

Excess vitamin B2 or riboflavin may also drop your blood pressure, causing hypotension

They also have an impact on NAMPT levels 6 , which fluctuate to meet cellular NAD+ demand

Even water can wash acid into the esophagus if theres not enough time to clear

How do you help parents make sense of this