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2 The pathophysiology of Parkinsons disease Parkinsons disease, first described by James Parkinson in 1817, is a complex, age-related, progressive, and multisystem neurodegenerative condition associated with dopaminergic neuronal loss and formation of -synuclein (-Syn) protein aggregation in neurons of the substantia nigra (SN) (Ben-Shlomo et al., 2024)

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Other risks are sharing straws when snorting cocaine, or through the sharing of household items such as razors and toothbrushes

Officials from the Department of Health and Social Care stressed that prevention remains the most effective way to reduce smoking-related harm, especially among younger populations who are more vulnerable to nicotine addiction