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While findings from this study are restricted to the animal model in which they were generated, they provide a structured example of how researchers have investigated glutathione peptides as part of a broader antioxidant strategy against the biochemical consequences of aging

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RES also inhibits LPS- and ATP-activated NLR family pyrin domain containing 3 (NLRP3) inflammasome and protects microglial cells from oxidative stress, proinflammatory cytokine production, and pyroptotic cell death resulting from inflammasome activation [79]

Despite the number and importance of such enzymes to cellular metabolism, few studies have been conducted to better understand the effects of MTX on cellular metabolic homeostasis or find metabolic fragilities that could be exploited clinically