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Kamerkar S, LeBleu VS, Sugimoto H, Yang S, Ruivo CF, Melo SA, Kalluri R

doi: 10.1136/bmj-2024-080952 4

Neurons are highly vulnerable to oxidative damage due to their high metabolic rate and limited capacity for regeneration (Cobley et al., 2018)

However, it should be noted that the influence of intracellular molecular oxygen on PpIX metabolism is multi-faceted, and more abundant and precise means are needed to characterize the biochemical changes caused by the generation of molecular oxygen inside cancer cells, such as to demonstrate whether it is involved in epigenetic modification of heme synthesis through multi-omics analysis (proteomics, genomics, transcriptomics, metabolomics) or to confirm whether molecular oxygen directly affects the supply of Fe 2+ in mitochondria through chemical reactions

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"We found that the reactive metabolites generated by our system trigger a form of cell death that bypasses the resistance mechanisms commonly seen with standard chemotherapy," said Assoc Prof Drum