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It is also essential to carefully assess the source of Met while measuring its potential effect on health

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On the other hand, while the activation of stable imines by chiral Brnsted acid catalysts has been extensively investigated in a variety of enantioselective Mannich reactions 25,26,27,28,29,30,31,32,33,34,35,36 , this electrophile-based activating protocol has not been applied to aminomethylation reactions with the in situ-generated formaldimines, probably owing to their generally unstable nature and the lack of steric environment on the carbon atom for efficient stereocontrols (Fig

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