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injection remains the gold standard for systemic models

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Although the Del69/70, K417N, N501Y, D614G, and P681H mutations can enhance the viral infection (with a reproduction number of 2.64.0) and Del143/145, K417N, T478K, E484A, and N501Y are related to the immune escape, the infection of Omicron variant has less impact on the lung and is unlikely to cause serious diseases compared with VOC Delta

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doi: 10.1001/jama.264.1.48 146 LevinePHJacobsonSPocinkiAGCheneyPPetersonDConnellyRRet al