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Biomarker-based patient selection, such as circulating oxidative stress markers (e.g., MDA, 8-OHdG), remains speculative and has not been integrated into trial designs

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A recent study by Lius team demonstrated that the broad-spectrum DUB inhibitor palladium pyrithione complex (PdPT) promote GPX4 degradation, but proteasome inhibitor bortezomib reverses its effect (Yang L

The MWDS paradigm models vicarious trauma relevant to chronic human stress [20, 44, 45], while daily 2 mg/kg THC from gestational day 3 to birth simulates moderate, clinically relevant exposure without inducing cannabinoid tetrad effects [46, 47, 48]

Isorhamnetin Inhibited Migration and Invasion via Suppression of Akt/ERK-Mediated Epithelial-To-Mesenchymal Transition (EMT) in A549 Human Non-small-cell Lung Cancer Cells

Therapeutic potential exists in targeting necroptosis markers (RIPK1, RIPK3, and MLKL) and IFN- signaling