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Moreover, neuropeptides like orexins regulate sleep-wake cycles and interact with monoaminergic pathways, further implicating their role in depression pathophysiology [83, 84]

A., Ryan, C

The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes

Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing 4 and 6 subunits

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