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Emerging evidence suggests that AKT1 is highly expressed in the mammalian brain and plays a crucial role in brain development 30,31

Dose-dependent effects of IL-17 on IL-13-induced airway inflammatory responses and airway hyperresponsiveness

Such signaling is involved in maintaining intestinal homeostasis and affects the functioning of the CNS [61]

These mouse studies appear relevant to human disease, as a large number of studies have shown that polymorphisms in PON1 are associated with increased risk for atherosclerosis (265)