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Unexpectedly, activation of p21, ICAM1, or SRXN1 was not observed (Supplementary Figure S5), although DNA ( Figure 6 ) is consistent with the lack of activation of an adaptive oxidative stress response pathway observed here and in a previous study (Tafazoli and OBrien, 2009)

doi: 10.1093/humrep/17.12.3162 59 MeekerJDSinghNPHauserR

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Such efforts will offer multidimensional strategies for atherosclerosis management and advance personalized therapy and drug development ( 4.10 Precision medicine and novel biomarkers Precision medicine shows great promise in atherosclerosis management, focusing on integrating multi-omics datagenomics, proteomics, metabolomics, and single-cell sequencingto build individualized risk prediction models and open new avenues for early warning and precise intervention

The plasmids described in this work were either constructed by Twist Bioscience or cloned using Gibson assembly and standard molecular biology techniques