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Regarding EA, in vitro studies in caco 2 cells show that it acts through NF-B and ERK1/2 inhibition, breaking the cycle of inflammation, oxidative stress, redox-sensitive pathway activation, and intestinal permeabilization [348]

During the meiotic stages MI and MII, the adhesion proteins at the centromere degrade, facilitating the separation of homologous chromosomes and sister chromatids

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Exp Neurol 342:113740 Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball LE, Comte-Walters S et al (2018) Nitration and glycation turn mature NGF into a toxic factor for motor neurons: a role for p75 NTR and RAGE signaling in ALS

When oxidative stress overwhelms cellular defenses, it can impair the 26S proteasome, leading to the accumulation of ubiquitinated proteins and disrupting protein homeostasis