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This axis is mediated by metabolites (such as amino acids and lactate), endocrine factors including myokines (e.g., IL-6, irisin, and BDNF), and neural pathways that integrate peripheral and central energy demands

45 In showing significant associations between latitude as a surrogate measure of UVR and the frequency of four gene polymorphisms that influence folate cofactor partitioning in folate metabolism, the present findings may provide new insight into folate-related diseases

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3-8 Porzionato A, Macchi V, Stecco C, Loukas M, Tubbs RS, De Caro R

doi: 10.1172/JCI12821 218 NeurathMFFussIKelsallBLPreskyDHWaegellWStroberW

Among these, transcranial direct current stimulation (tDCS) has emerged as a compelling modality, demonstrating efficacy across a range of pain conditions, coupled with a favorable safety profile and low incidence of adverse effects (7, 8)