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Excessive autophagy can lead to metabolic stress and degradation of cellular components, which exacerbates the structural destruction and functional decline of tissues ( 2 O 2 -induced autophagy with a decreased expression of autophagy marker proteins LC3-II and Beclin-1

Dysregulated metabolism contributes to oncogenesis

Alcohol increases NAPQI production by inducing CYP2E1, exacerbating liver injury even with moderate acetaminophen doses

Biomaterials 224 , 119491 (2019)

2.2 Toxicological mechanism associated with Cd exposure Cadmium (Cd) is ubiquitously present in environmental matrices such as air, water, soil, and biological tissues, existing predominantly in bound forms rather than in its elemental state

doi: 10.1186/s40478-019-0874-4 148 TarrISMcCannEPBenyaminBPetersTJTwineNAZhangKYet al