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Michel JP

& Nassir, A

Furthermore, multiple studies have demonstrated that collagen peptides can inhibit the expression of pro-inflammatory factors, such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), IL-6, IL-8, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), in fibroblasts and keratinocytes, thereby mitigating inflammatory responses [32, 33]

Karrabi et al., 2021)

Following reports of its efficacy in several case series of pemphigus patients [21], a multicenter RCT with 72 patients with PV/PF investigated safety and efficacy of best medical treatment (prednisolone 1 mg/kg/day plus azathioprine or mycophenolate) with and without adjuvant IA