Cho SG, Woo SM, Ko SG (2014) Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species
While all of our picks contain ingredients with at least some scientific support, Wholesome Storys Inositol Capsules (with vitamin D and folate) have a particularly strong evidence base for women dealing with polycystic ovary syndrome (PCOS)
Ribociclib Ribociclib has shown efficacy in both metastatic and early-stage HR+/HER2 breast cancer
6 AssuncaoM.AndradeJ
Institutional review board Not applicable
In a murine model of albumin-overload kidney disease, tubular cell-specific knockdown of RTN1A blunted ER stress and apoptosis of tubular cells, and reduced kidney fibrosis ( These findings are of relevance from a translational perspective since, besides 4-phenylbutyric acid, additional drugs approved for clinical use, albeit not for chronic kidney disease (CKD), are able to alleviate ER stress (e.g., sunitinib, approved for renal cell carcinoma, or tauroursodeoxycholic acid, approved for primary biliary cirrhosis) ( Involvement of autophagy impairment in proteinuria-induced tubular cell apoptosis and tubular injury Similarly to ER stress, autophagy can lead to either cell survival or death depending on the degree and type of stress