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This method comprises contacting a cell with a ferroptosis modulator, which comprises a compound having the structure of formula (I): R 1 and R 2 , are independently selected from the group consisting of no atom, H, D, O, halo, C 1-6 alkyl, C 1-6 alkyl-aryl, C 1-6 alkyl-heteroaryl, C 1-6 alkenyl, C 1-6 alkenyl-aryl, and C 1-6 alkenyl-heteroaryl, wherein the C 1-6 alkyl, C 1-6 alkyl-aryl, C 1-6 alkyl-heteroaryl, C 1-6 alkenyl, C 1-6 alkenyl-aryl, and C 1-6 alkenyl-heteroaryl may be optionally substituted with an atom or a group selected from the group consisting of halo, deuterium, C 1-4 alkyl, CF 3 , and combinations thereof

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During the 120 days of their lifespan, RBCs are charged with carrying oxygen from lungs through the oxyhemoglobin (Fe 2+ ) and transferring it to tissues, including those in the brain, which is characterized by a high oxidative milieu [9]