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demonstrated that caspase-4 and -11 are activated in response to Gram-negative bacteria in intestinal epithelial cells (IECs) and that this activation was indispensable for pathogen clearance and GI homeostasis ( Pyroptosis Independent Functions A number of pyroptosis-independent roles for non-canonical inflammasome associated caspases, particularly caspase-11, are emerging and are reviewed in more detail elsewhere ( CASP11 deficiency leads to increased IEC proliferation and angiogenesis, which are usually repressed by STAT1 activity ( et al

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Nishida Y, Kojima K, Maeda A, Chachad D, Kitamura H, Ishizawa J, Andreeff M , Kornblau S, Kimura S

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