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In summary, these natural products achieve multi-level comprehensive intervention in viral pneumonia models, from inhibiting viral replication and alleviating the release of inflammatory factors to regulating oxidative stress and tissue protection, by synergistically inhibiting PI3K/Akt and its cross-signaling axes, such as Nrf2, NF-B, NLRP3, establishing a natural drug action mechanism centered on integrated regulation of signaling pathways, providing theoretical support for the subsequent development of multi-target anti-inflammatory and antiviral drugs

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