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Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2/ mice

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Similarly, xanthine oxidase, an enzyme involved in purine metabolism, can generate superoxide and hydrogen peroxide as by-products, particularly under conditions of oxidative stress or tissue damage [48]

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Acta 1830 , 31393142 (2013)

However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Ghezzi, 2011) GSH acts to regulate the thresholds necessary for immunologic activation through redox-sensitive signal transduction pathways, influences antigen presentation and the development/differentiation of immune cells, and modulates the production of cytokines