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222 In a randomized controlled trial in elderly patients with mild cognitive impairment living in the United Kingdom, supplementing with 800 mcg folic acid, 500 mcg B 12 , and 20 mg B 6 daily for two years reduced atrophy of gray matter (brain tissue most vulnerable to Alzheimer pathology) up to seven-fold in those with baseline homocysteine levels higher than 11 mol/L

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Effect of combination folic acid, vitamin B6 , and vitamin B12 supplementation on fracture risk in women: a randomized, controlled trial

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The Framingham Offspring Study first observed that vitamin B-12 from milk was better absorbed than meat

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