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Macrophages and endothelial cells produce large amounts of IL-6, which activates T cells and other immune cells and creates a positive feedback loop leading to a cytokine storm, which induces the release of more cytokines and chemokines, as well as the upregulation of acute phase proteins

S., Koller, A., Stephanie, G

T2DM subjects also had decreased levels of IFN- ( Figure 3E ) and TNF- ( Figure 3F ) in the plasma samples when compared to healthy subjects

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doi: 10.1245/s10434-007-9733-9 43 PortolaniNTiberioGARonconiMConiglioAGhidoniSGaveriniGet al

Cerebral energy metabolism and intracellular pH during severe hypoxia and recovery: a study using 1H, 31P and 1H[13C] NMR spectroscopy in the guinea pig cerebral cortex in vitro