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After a single injection, mean plasma IGF-1 concentrations increased 1.5 to 3-fold for 9 to 11 days

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It inhibits lipogenesis (the formation of new fat from non-fat substrates) meaning fewer calories may be converted into stored fat

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Unfortunately, VEGF can also be detrimental because its overexpression can cause inflammation in the nervous system, which in turn can lead to BBB leakage, promote the production of pro-inflammatory cytokines and the occurrence of neurodegeneration (Claire and Larrive 2017