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The initial dose of amlodipine was 5 mg for 2 weeks with forced titration to 10 mg for 2 weeks, followed by optional titration to 10 mg for 4 weeks and optional addition of hydrochlorothiazide 12.5 mg for 4 weeks

Conversely, the expression of NRF2-target genes was shown to be enhanced in silenced BACH1 cells from older subjects (Zhang et al., 2019)

Oxidative stress and neuroinflammation are increasingly recognized as central elements in its development, with mitochondrial dysfunction and weakened antioxidant systems playing a significant role

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Glutathione S-transferase T1 (GSTT1) null polymorphism, smoking, and their interaction in coronary heart disease: a comprehensive meta-analysis

An increase in ROS levels has also been shown to increase nonspecific cation conductance of the plasma membrane, thus affecting the osmotic balance of the cell