It is also known to interact with Nrf2, a key transcription factor that activates antioxidant response elements (ARE)
Het verschil tussen gereduceerd en geoxideerd
TABLE 2 Active metabolites developed as drugs Metabolite drugs Parent drugs Acetaminophen Phenacetin Cetirizine Hydroxyzine Desimipramine Imipramine Desloratadine Loratadine Digoxin -methyldigoxin Fexofenadine Terfenadine (withdrawn due to cardiotoxicity) Mesoridazone Thioridazone Morphine Codeine Nortriptyline Amitriptyline Oxazepam Diazepam Phenobarabital Primidone N-Acetylprocainamide Procainamide (A
T.LipsonR
While no antagonistic interactions were observed, this screening approach identified synergistic effects between loss of ABCC1 or ABCA2 and Venetoclax treatment (Fig
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