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When evaluating side effects, the following frequencies are used as a basis: Very common: more than 1 in 10 people Common: less than 1 in 10, but more than 1 in 100 patients Uncommon: less than 1 in 100, but more than 1 in 1000 patients Rare: less than 1 in 1,000 but more than 1 in 10,000 patients Very rare: less than 1 in 10,000 patients treated, or unknown

B12 injection doses can range from 100 mcg to 1,000 mcg, depending on the person, their age, and their condition

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Furthermore, recent findings suggest that CD38 deficiency protects the heart from I/R injury by activating SIRT1/FOXOs-mediated and Sirt3/FOXO3-mediated anti-oxidative stress pathways [25, 26] (Fig