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Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimers Disease Model

doi:10.3945/ajcn.114.091819

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( i ) Quantification of H2AX foci in cells expressing empty vector or CCNE1 transduced with shRNAs targeting TMLHE alone (shTMLHE) or supplemented with propionylcarnitine or butyrylcarnitine (n = 3 technical replicates representative from 2 independent experiments in each cell line)

Some of these immunosuppressive medications may directly interfere with glycolysis, mitochondrial function, lipogenesis, and amino acid metabolism, but mechanistic understanding of such effects remains scarce

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