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The PLS-DA and heat map in Figure 1 show that resistant cells treated continuously with 1 M tamoxifen (4+1), a concentration that is often measured in patients (24), showed different metabolic clusters compared to the other two resistant groups (50 and 35x6) and the control (tamoxifen-sensitive) group, indicating that they had markedly different metabolic characteristics ( Figure 1A )

Of note, the medium and high doses were able to increase glycine levels close to the median level observed in young individuals (Figure 5, red dashed line)

However, limitations such as variable patient responses, potential side effects, and the need for individualized treatment plans highlight the ongoing challenges in treating liver cirrhosis effectively