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Around 74% of participants also achieved an A1C of 6.5% or less, indicating that CagriSema could be another effective treatment option for type 2 diabetes and weight management

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However, a long enrollment period was necessary owing to the inclusion of genetic studies

Gut microbe-derived metabolites such as ROS and lipopolysaccharides can leak into the body circulation via a bidirectional microbe-gut-brain axis communication system, and these neurotoxin releases from the gut microbiota can elicit an inflammatory response and cross the bloodbrain barrier to modulate neuronal activity, and neuroinflammation has been implicated in the pathogenesis of diabetes mellitus and its associated cognitive dysfunction (124)

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