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This study was supported by the Shandong University of Traditional Chinese Medicine Doctoral Student Quality Improvement Innovation Project (YJSTZCX2024018), the Inheritance Studio of Traditional Chinese Medicine Master Zhang Canjia of State Administration of Traditional Chinese Medicine (no.(2010) 59), the Chinese Medicine Science and Technology Project of Shandong Province in 2023 (M-2023031), and the Key Project of Undergraduate Teaching Reform Research in Shandong Province (Z2023292)

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Available from: Heintjes EM, Berger M, Bierma-Zeinstra SMA, Bernsen RMD, Verhaar JAN, Koes BW

Furthermore, the inclusion of 10 mg of Vitamin B6 as Pyridoxal-5-Phosphate (P-5-P) provides the critical spark for this entire metabolic engine

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GLP-1R-mediated effects include [8]: Glucose-dependent insulin secretion (complementary to GIP pathway) Glucagon suppression during hyperglycemia Delayed gastric emptying Central appetite suppression via hypothalamic and brainstem circuits Synergistic Mechanisms The dual agonism of tirzepatide produces several synergies that explain its superior efficacy: Complementary appetite suppression : GIP and GLP-1 receptors are expressed on distinct neuronal populations in the hypothalamus