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& Tepper, J

The RxPepsDirect starting protocol is 25 units (1.5 mg) on a U-100 insulin syringe, taken subcutaneously twice weekly, for a total of 3 mg per week

10.1016/S0140-6736(21)02143-7 3

161 Gut-derived indole metabolites and bacterial tryptophanase activate AhR signaling in astrocytes and microglia, suppressing NF-B, inhibiting NLRP3 inflammasome formation, and reducing pro-inflammatory cytokines, thereby alleviating neuroinflammation and improving microglial reactivity in AD models such as APP/PS1 and experimental autoimmune encephalomyelitis mice