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NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia

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Glutathione neutralizes reactive compounds, protects cells from oxidative stress, and facilitates the excretion of toxins by forming water-soluble conjugates

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The level of thymidylate synthase (TS) protein was also high in the heart tissue (100)