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thin-plate regression splines and restricted maximum likelihood (REML) were used to fit the models

NF-kBnuclear factor kappa-light-chain-enhancer of activated B cells

At certain conditions like cardiac I/R, this leakage reduces O 2 production by the electron transport chain, thus, UCPs are considered protective proteins against oxidative stress (Cadenas, 2018

When the carboxylic acid group donates its hydrogen, or partially donates it, it becomes COO

Taken together, these studies reveal that MTHFD2 engages in diverse non-enzymatic functions beyond folate metabolism, supporting genomic stability, protein synthesis, and tumor cell adaptation and growth