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Several studies have suggested that in dopaminergic neurons of the substantia nigra, the high GSSG/GSH ratio leads to Grx2 inhibition, causing a mitochondrial iron overload that deters the functions of complex I and aconitase, a tricarboxylic acid cycle (TCA) enzyme involved in converting citrate to isocitrate [29]

2025 [cited 16th Oct 2025] Pyridoxine - Fact Sheet for Health Professionals [Internet]

What the research shows 1

You may develop a vitamin B12 deficiency if you dont get enough vitamin B12 from food or supplements, or if your body has trouble absorbing it from your digestive system