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Capsid-optimized adenovirus-associated virus 8 vectors was used to deliver the CRISPR-CasRx system to pancreatic cancer in situ tumors and patient-derived tumor xenografts, demonstrating that CasRx accurately and efficiently silenced the expression of Kras G12D mutants in pancreatic ductal adenocarcinoma cells guided by Kras G12D -specific gRNA

Metformin, a well-established treatment for Type 2 diabetes, has increasingly been applied to address IR in recent years (92)

Probiotics and prebiotics: Present Status and Future Perspectives on Metabolic Disorders

Consequently, therapeutic strategies have shifted toward indirect, receptor-mediated modulation

nonetheless, they can be equally as debilitating as motor symptoms for many patients

Funding This work was supported by Beijing Natural Science Foundation (Grant No