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This is what NICE CKS states, that if B12 deficiency is

provided one of the first demonstrations of the importance of NO in endothelial regulation of blood pressure in a mouse knockout of eNOS, in which animals developed severe hypertension and loss of acetylcholine-induced vasodilation ( / mice significantly improved cardiac function, implicating PECAM-1 as a regulator of cardiac function via paracrine NRG-ErbB2 signaling (Nakagawa et al., 2016)

Scientists have explored different theories, but the most compelling include: 1

Beinart N, Hackett RA, Graham CD, Weinman J, Ostermann M (2015) Mood and illness experiences of adults with cystinosis

Wild-type IDH2 contributes to Epstein-Barr virus-dependent metabolic alterations and tumorigenesis

doi: 10.1016/j.cell.2008.01.020 94