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In terms of the magnitude of fat mass reduction in controlled research settings: Semaglutide (GLP-1 alone): ~1015% body weight Tirzepatide (GLP-1 + GIP): ~1622% body weight Retatrutide (GLP-1 + GIP + Glucagon): ~2429% body weight (Phase 2 data) This stepwise increase with each additional receptor target is a remarkable demonstration of pharmacological synergy and has driven enormous interest in the triple-agonist research space

Clemmons DR, Moses AC, Sommer A, Jacobson W, Rogol AD, Sleevi MR, Allan G

Journal of Endocrinology.

These symptoms usually resolve within a day or two

Others schedule maintenance to help keep levels steady, especially if they follow a plant-forward diet, take certain medications that affect absorption, or have a history of deficiency

Vitamin B12 is usually prescribed as a supplement to treat nerve damage due to its ability to preserve healthy nerve cells