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Silibinin also prevents mitogenic signaling by reducing Epidermal Growth Factor Receptor (EGFR), ERK1/2, protein kinase B (PKB), and signal transducer and activator of transcription 3 (STAT3) phosphorylation and suppressed the activation of transcription factors NF-B and activator protein 1 (AP-1) (92)

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MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients

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