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202140208), and National Key Research and Development Program of Peoples Republic of China (grant no

Handbook of Pr oteol ytic Enzymes (Third Edition) (eds Neil D

7a, and Supplementary Figs

in this context, reduced synthesis or impaired function of hepcidin leads to ineffective inhibition of FPN, resulting in increased intestinal iron absorption and excessive release of stored iron from macrophages and hepatocytes, culminating in systemic iron overload that, when deposited in the heart, causes myocardial damage [90]

One critical mechanism through which gut bacteria influence inflammation involves the production of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate (Zhou et al., 2024)