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Sclerosis of interlobular and arcuate arteries, tubular atrophy and glomerular scarring are late features of RN [56, 57]

Shapiro, W., Wasserman, A

This includes people with pernicious anemia, autoimmune disorders, or conditions that affect nutrient absorption

Most peptides described here are not approved by the FDA for treating autoimmune conditions

Redundant stacks Avoid : Multiple peptides with identical mechanisms Examples of redundant stacks : Semaglutide + Tirzepatide (both GLP-1 agonists, no added benefit) Ipamorelin + Sermorelin + CJC-1295 (all GH releasers, excessive) Multiple healing peptides beyond BPC-157 + TB-500 + GHK-Cu Problem : Wasted money, no synergy, potentially excessive dosing Better : Choose the most effective from each category Conflicting goals Avoid : Stacks with opposing mechanisms Example : Extreme weight loss + muscle growth stack Semaglutide : Severe calorie deficit Ipamorelin/CJC-1295: Need surplus for muscle growth Conflict : Can't be in deficit and surplus simultaneously Solution : Focus on one primary goal, support with complementary peptides Overly complex stacks Problem with 5+ peptides : Difficult to manage dosing Can't tell what's working Excessive injection frequency Very expensive Higher side effect risk Recommendation : Maximum 3-4 peptides in a stack Exception : Experienced users may handle more complex protocols Incompatible safety profiles Consider individual contraindications : Example issue : Someone with pancreatitis history Should avoid GLP-1 peptides (semaglutide/tirzepatide) Can use BPC-157, TB-500, Ipamorelin safely Example issue : Active cancer concerns Should avoid growth-promoting peptides (GH releasers) Healing peptides generally okay (consult doctor) Read our peptide safety guide

Rakel 2011