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Under healthy conditions, microbial metabolites particularly short-chain fatty acids (SCFAs) such as butyrate suppress IDO activity and constrain peripheral KP flux

When researchers knocked down TGF-beta1, the osteogenic effects of MOTS-c were reversed, confirming this pathway as the primary mechanism

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Such inhibition leads to the accumulation of sterol precursors and the depletion of an essential component of the fungal membrane [165]

Trends Biochem Sci 38:592602 Keszler A, Zhang Y, Hogg N (2010) Reaction between nitric oxide, glutathione, and oxygen in the presence and absence of protein: how are S-nitrosothiols formed

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