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On the other hand, dose-response relationships for these peptides are often biphasic or bell-shaped, meaning that more is not better and that higher concentrations can lose the effect or even reverse it

The lipid peroxidation product 4-Hydroxy-2-nonenal: Advances in chemistry and analysis

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The CMDI, serving as a macroscopic assessment of extensive injury in the specimens, was markedly increased in the DSS group

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doi:10.1093/bmb/ldy035