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Current research has explored the combined application of HK2 inhibitors (e.g., 2-DG) and AMPK agonists (e.g., Metformin) in RA models, demonstrating synergistic inhibitory effects on synovitis and bone erosion

It is an organic oxidative compound widely used in oxidation processes as a selective and inexpensive oxidizing agent 12,13,14,15,50

3 A higher numeric value on the Finnegan score indicates more severe withdrawal, and treatment with opioids generally is initiated when the scores average 8 or greater

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When the HSC70 chaperone complex translocates to the lysosomal membrane, molecular chaperones within the lysosomal lumen facilitate the translocation of the substrate complex across the membrane, wherein LAMP2A plays a pivotal receptor role

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