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B Vitamins Vitamin B12 is absorbed in only one part of the small intestine, known as the ileum, right before it joins the colon, says King

If you experience fatigue that is ongoing and unexplained neurological symptoms like numbness, or if you are struggling to concentrate, it is best to discuss any concerns with your medical provider

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Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives

Situations where oral administration is not feasible (e.g., anorexia, nausea, pre-op, GI absorption issues)