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Strebinger, D., Frangieh, C

A.ShamitkoZ

"Glypican-3: a new target for cancer immunotherapy"

Inflammation creeps in

Simultaneously, CoQ10, an essential component of the mitochondrial electron transport chain, not only supports ATP synthesis but also modulates inflammation by inhibiting the release of pro-inflammatory cytokines and by down-regulating the NLRP3 inflammasome 53

Usually, MyD88- and TRIF-dependent signaling pathways are triggered consecutively, due to the redistribution of the LPS-activated TLR4 from plasma membrane to the endosomes, leading to its lysosomal degradation and termination of the inflammatory response [24]