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GSH is then converted into oxidized glutathione (GSSG) via GPX4, thus reducing the amount of lipid-based reactive oxygen species (ROS) ( 3+ into cells

Moreover, when looking at the early phase of histological liver damage in patients abusing of alcohol beverages, the presence of protein adducts in the centrilobular region of the liver (the same one interested in opioid cytotoxicity) shows that adducts formation is one of the leading events in the molecular processes displayed during the ALD (Niemel, 1999)

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Experimental Dermatology, 34 (2), e70042

Our data indicate that PUFAs trigger GPX4-restricted mucosal inflammation resembling some aspects of human CD

Therefore, modulation of FFA-mediated pathways involved in endothelial dysfunction may prevent the complications associated with CVD risk