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Elevated cholinesterases, including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), impair acetylcholine and are found in dementia [1012]

To achieve a plasma level of 0.7mM (less than the 1mM used int he paper), you have to give a rat 150mg/kg/day IV, which is the equivalent of a 1451mg IV SAMe daily dose to a 60kg human, but since the oral absorption is around 5%, that's the equivalent of more than a 29,000mg daily oral dose

Our study conceptualizes a dual mode of action by which metronidazole and 5-nitroimidazole ethers induce stress and simultaneously inhibit the stress response with deleterious effects on bacterial survival

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Synergistic interactions between growth hormonereleasing hormone and secretagogues in experimental models. Journal of Neuroendocrinology