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Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method

Koschmieder S, D'Al F, Radomska H, Schneich C, Chang JS, Konopleva M, Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M , Sporn MB, Perrotti D, Berdel WE, Mller-Tidow C, Serve H, Tenen DG

Herein, the genetic susceptibility mechanisms of IBD, the specific impacts of environmental and lifestyle factors, and their interactive patterns are systematically reviewed, with particular emphasis on the mechanistic pathways of modifiable factors, with the aim of providing practical guidance for the development of personalized prevention strategies and therapeutic interventions

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