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Oncotarget 7 , 67116726 (2016)

Kennedy L, Sandhu JK, Harper ME, Cuperlovic-Culf M

It can gradually evolve from alcoholic fatty liver to alcoholic steatohepatitis (ASH)

To limit potentially life-threatening depletion of intracellular antioxidant/GSH stores, epithelial cells have developed numerous compensatory pathways, including the cystine-glutamate antiporter (SLC7A11), which critically maintains de novo GSH biosynthesis by increasing intracellular cystine levels (9)