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Immunological insignificance may have been due to low drug adherence for over one-third of the study duration

Pattern of injury is often mixed pattern or cholestatic and competing etiologies such as extra-hepatic causes of cholestasis and DILI should be excluded

Human Aurora-A kinase domain (122403, N332A Q335A T347A D350A C290A C393A D274N, Aurora-A M7KD ) with no tag was cloned into the pCDF vector with spectinomycin resistance

Chem Res Toxicol 14:10511057 Acknowledgements This study was partially supported by Grant-in-aid for Scientific Research (14390058) from The Japan Society for Promotion of Science